Cervantes, Forne, Ranjit, Gratton, and Sassone-Corsi
Sato, Bunney, Vawter, Bunney, Sassone-Corsi
Greco, Koronowski, and Sassone-Corsi
Have you ever asked yourself why you have energy during the day and feel tired at night? What if I told you that there is a part of your body that is secretly controlling these feelings without you knowing? Well there is! It is called your biological clock or circadian rhythm, and it is ticking away inside you right now. What is really amazing is that your biological clock collects information from the outside world, such as sunlight and food, and sets your body’s time to match it. The times when you choose to eat might move your body’s clock forwards or backwards, and what you eat can make your clock stronger or weaker. Eating and sleeping are great, but your biological clock does so much more for you. The good news is all you need to do is listen to it and it will help keep you healthy.
Gaucher, Kinouchi, Ceglia, Montellier, Peleg, Greco, Schmidt, Forne, Masri, Baldi, Imhof, and Sassone-Corsi
Alcohol drinking is a widespread habit in modern society and can cause deleterious metabolic consequences. Recent studies have uncovered the interplay between nutrition, metabolism, and circadian rhythms. Here we explore the effects of alcohol consumption on circadian physiology. We employed unbiased high-throughput proteomics, acetylomics, and circadian transcriptomics to provide a comprehensive analysis of liver metabolism and compared the outcomes of acute and chronic alcohol consumption.
Dyar, Lutter, Artati, Ceglia, Liu, Armenta, Jastroch, Schneider, de Mateo, Cervantes, Abbondate, Tognini, Orozco-Solis, Kinouchi, Wang, Swedloff, Nadeef, Masri, Magistretti, Orlando, Borrelli, Uhlenhaut, Baldi, Adamski, Tschop, Eckel-Mahan, and Sassone-Corsi
Metabolic diseases are often characterized by circadian misalignment in different tissues, yet how altered coordination and communication among tissue clocks relate to specific pathogenic mechanisms remains largely unknown. Applying an integrated systems biology approach, we performed 24-hr metabolomics profiling of eight mouse tissues simultaneously.
Koronowski, Kinouchi, Welz, Smith, Zinnam Shi, Samad, Chen, Magnan, Kinchen, Li, Baldi, Benitah, and Sassone-Corsi
An autonomous branch of the liver circadian clock is independent from all other clocks yet still dependent on the light-dark cycle.
Well, Inna, Symeonidi, Koronowski, Kinouchi, Smith, Guillén, Castellanos, Crainicius, Prats, Caballero, Hidalgo, Sassone-Corsi, and Benitah
We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single tissues in the absence of Bmal1 in all other tissues. Strikingly, light-driven tissue autonomous clocks occur without rhythmic feeding behavior and are lost in constant darkness. Importantly, tissue-autonomous Bmal1 partially sustains homeostasis in otherwise arrhythmic and prematurely aging animals.
Pastore, Vainshtein, Herz, Huynh, Brunetti, Klisch, Mutarelli, Annunziata, Kinouchi, Brunetti-Pierri, Sassone-Corsi, and Ballabio
Autophagy and energy metabolism are known to follow a circadian pattern. However, it is unclear whether autophagy and the circadian clock are coordinated by common control mechanisms. Here, we show that the oscillation of autophagy genes is dependent on the nutrient‐sensitive activation of TFEB and TFE3, key regulators of autophagy, lysosomal biogenesis, and cell homeostasis.
Aras, Ramadori, Kinouchi, Liu, Loris, Brenachot, Ljubicic, Veyrat-Durebex, Mannucci, Gailé, Balid, Sassone-Corsi, and Coppari
Loss of synchrony between geophysical time and insulin action predisposes to metabolic diseases. Yet the brain and peripheral pathways linking proper insulin effect to diurnal changes in light-dark and feeding-fasting inputs are poorly understood. Here, we show that the insulin sensitivity of several metabolically relevant tissues fluctuates during the 24 hour period.
Distinct response of metabolic cycles in skeletal muscle to time-of-day exercise. Early active phase exercise exerts a robust metabolic response in skeletal muscle. The metabolic response includes glycolysis, lipid oxidation, and BCAA breakdown. Time of exercise specifies the activation of HIF1α and systemic energy expenditure.
Sato, Basse, Schonke, Chen, Samad, Altintas, Laker, Dalbram, Barres, Baldi, Treebak, Zierath, and Sassone-Corsi
Cervantes and Sassone-Corsi
The function of histone proteins can be modified through addition or removal of certain chemical groups. The addition of a serotonin molecule is a newly found histone modification that could influence gene expression.
Greco and Sassone-Corsi
The circadian clock is an endogenous, time-tracking system that directs multiple metabolic and physiological functions required for homeostasis. The master or central clock located within the suprachiasmatic nucleus in the hypothalamus governs peripheral clocks present in all systemic tissues, contributing to their alignment and ultimately to temporal coordination of physiology. Accumulating evidence reveals the presence of additional clocks in the brain and suggests the possibility that circadian circuits may feed back to these from the periphery. Here, we highlight recent advances in the communications between clocks and discuss how they relate to circadian physiology and metabolism.
Kinouchi, Magnan, Ceglia, Liu, Cervantes, Pastore, Huynh, Ballabio, Baldi, Masri, and Sassone-Corsi
The circadian clock operates as intrinsic time-keeping machinery to preserve homeostasis in response to the changing environment. While food is a known zeitgeber for clocks in peripheral tissues, it remains unclear how lack of food influences clock function. We demonstrate that the transcriptional response to fasting operates through molecular mechanisms that are distinct from time-restricted feeding regimens.
Masri and Sassone-Corsi
The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, the use of animal models and molecular studies indicate emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches and we discuss the possible design of chrono-pharmacological strategies.